Basic and clinical research in the AMC Renal Transplant Unit.

Abstract

Our research is aimed at characterization of the antiviral and allo-immune responses in kidney transplant recipients. In particular, we are interested in the differentiation, effector function and memory formation of T cells specific for the latent viruses cytomegalovirus (CMV) and BK virus (BKV) and in the impact of virus-specific immune responses on alloimmunity. Furthermore, we perform studies towards the most optimal, tailor-made immunosuppressive drug regimen and towards the impact of immunosuppression on infectious diseases; cognitive function and cardiovascular status of kidney transplant recipients.

• Authors: Ineke J M ten Berge, Fréderike J Bemelman
• Journal: Transplant immunology (Transpl Immunol) Vol. 31 Issue 4 Pg. 210-2 (Oct 2014) ISSN: 1878-5492 [Electronic] Netherlands
• PMID: 25240734 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Antiviral Agents
• Immunosuppressive Agents

Topics

• Antiviral Agents (therapeutic use)
• BK Virus (immunology)
• Biomedical Research
• Cognitive Dysfunction (complications)
• Cross Reactions (immunology)
• Cytomegalovirus (immunology)
• Cytomegalovirus Infections (immunology)
• Depression (complications)
• Fatigue (complications)
• Humans
• Immunologic Memory (immunology)
• Immunosuppression Therapy
• Immunosuppressive Agents (therapeutic use)
• Kidney (immunology, surgery, virology)
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation (adverse effects)
• Netherlands
• Polyomavirus Infections (immunology)
• T-Lymphocytes (immunology)
• Viremia (drug therapy, virology)