Genetic variants of PLA2G6 are associated with Type 2 diabetes mellitus and triglyceride levels in a Chinese population.

Abstract

AIM:

To test the association of PLA2G6 variants with Type 2 diabetes and clinical characteristics in large Chinese population-based samples.

METHODS:

A total of 6822 people were recruited. In the first stage, 15 single nucleotide polymorphisms within the PLA2G6 region were selected and genotyped in 3700 Chinese Han people. In the second stage, the single nucleotide polymorphisms that showed a significant association were genotyped in an additional 3122 samples for replication. Genotype-phenotype association studies and meta-analyses were performed after combining data from the two stages.

RESULTS:

In the first stage, we detected rs132984 and rs2284060 as significantly associated with Type 2 diabetes with odds ratios of 1.247 (95% CI 1.074-1.449, P = 0.004, empirical P = 0.047) and 1.173 (95% CI 1.059-1.299, P = 0.002, empirical P = 0.029), respectively. In the second stage, a similar effect of rs132984 on Type 2 diabetes was observed (odds ratio 1.280, 95% CI 1.094-1.497, P = 0.002). The meta-analysis showed a significant effect of the two single nucleotide polymorphisms on Type 2 diabetes (odds ratio 1.254, 95% CI 1.104-1.451, P = 4.85 × 10⁻⁵ for rs132984; odds ratio 1.120, 95% CI 1.046-1.195, P = 0.003 for rs2284060). Moreover, genotype-phenotype association analysis showed that rs132984 was associated with triglyceride levels (P = 0.022, empirical P = 0.044) and area under the curve for glucose (P = 0.015, empirical P = 0.030).

CONCLUSIONS:

Our data imply that common single nucleotide polymorphisms within the PLA2G6 region are associated with Type 2 diabetes and triglyceride levels in the Chinese population.

• Authors: J Yan, C Hu, F Jiang, R Zhang, J Wang, S Tang, D Peng, M Chen, Y Bao, W Jia
• Journal: Diabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 32 Issue 2 Pg. 280-6 (Feb 2015) ISSN: 1464-5491 [Electronic] England
• PMID: 25207958 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.

Chemical References

• Triglycerides
• Group VI Phospholipases A2
• PLA2G6 protein, human

Topics

• Alleles
• Asian People
• Case-Control Studies
• China
• Diabetes Mellitus, Type 2 (blood, complications, genetics)
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Group VI Phospholipases A2 (genetics)
• Humans
• Hypertriglyceridemia (complications, genetics)
• Linkage Disequilibrium
• Male
• Polymorphism, Single Nucleotide
• Triglycerides (blood)