Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats.

Abstract

In our previous study, fish protein was proven to reduce serum lipids and body fat accumulation by skeletal muscle hypertrophy and enhancing basal energy expenditure in rats. In the present study, we examined the precise effects of fish protein intake on different skeletal muscle fiber types and metabolic gene expression of the muscle. Fish protein increased fast-twitch muscle weight, reduced liver triglycerides and serum glucose levels, compared with the casein diet after 6 or 8 weeks of feeding. Furthermore, fish protein upregulated the gene expressions of a fast-twitch muscle-type marker and a glucose transporter in the muscle. These results suggest that fish protein induces fast-muscle hypertrophy, and the enhancement of basal energy expenditure by muscle hypertrophy and the increase in muscle glucose uptake reduced liver lipids and serum glucose levels. The present results also imply that fish protein intake causes a slow-to-fast shift in muscle fiber type.

• Authors: Fuminori Kawabata, Takafumi Mizushige, Keisuke Uozumi, Kohsuke Hayamizu, Li Han, Tomoko Tsuji, Taro Kishida
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 79 Issue 1 Pg. 109-16 ( 2015) ISSN: 1347-6947 [Electronic] England
• PMID: 25198797 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Caseins
• Dietary Proteins
• Fish Proteins
• Glucose Transporter Type 4
• Peroxisome Proliferator-Activated Receptors
• Slc2a4 protein, rat
• Triglycerides
• Carnitine O-Palmitoyltransferase
• Myosin Heavy Chains

Topics

• Adipose Tissue (drug effects)
• Animals
• Blood Glucose (drug effects, metabolism)
• Body Weight (drug effects)
• Carnitine O-Palmitoyltransferase (genetics, metabolism)
• Caseins (administration & dosage, metabolism)
• Dietary Proteins (administration & dosage, metabolism)
• Energy Metabolism
• Fish Proteins (administration & dosage, metabolism)
• Fishes (metabolism)
• Gene Expression Regulation
• Glucose Transporter Type 4 (genetics, metabolism)
• Hypertrophy (chemically induced, metabolism, pathology)
• Insulin Resistance
• Liver (drug effects, metabolism)
• Male
• Muscle Fibers, Fast-Twitch (drug effects, metabolism)
• Muscle Fibers, Slow-Twitch (drug effects, metabolism)
• Myosin Heavy Chains (genetics, metabolism)
• Peroxisome Proliferator-Activated Receptors (genetics, metabolism)
• Rats
• Rats, Sprague-Dawley
• Triglycerides (metabolism)