Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

Abstract

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

• Authors: Joo-Yeon Hwang, Xueling Sim, Ying Wu, Jun Liang, Yasuharu Tabara, Cheng Hu, Kazuo Hara, Claudia H T Tam, Qiuyin Cai, Qi Zhao, Sunha Jee, Fumihiko Takeuchi, Min Jin Go, Rick Twee Hee Ong, Takayoshi Ohkubo, Young Jin Kim, Rong Zhang, Toshimasa Yamauchi, Wing Yee So, Jirong Long, Dongfeng Gu, Nanette R Lee, Soriul Kim, Tomohiro Katsuya, Ji Hee Oh, Jianjun Liu, Satoshi Umemura, Yeon-Jung Kim, Feng Jiang, Shiro Maeda, Juliana C N Chan, Wei Lu, James E Hixson, Linda S Adair, Keum Ji Jung, Toru Nabika, Jae-Bum Bae, Mi Hee Lee, Mark Seielstad, Terri L Young, Yik Ying Teo, Yoshikuni Kita, Naoyuki Takashima, Haruhiko Osawa, So-Hyun Lee, Min-Ho Shin, Dong Hoon Shin, Bo Youl Choi, Jiajun Shi, Yu-Tang Gao, Yong-Bing Xiang, Wei Zheng, Norihiro Kato, Miwuk Yoon, Jiang He, Xiao Ou Shu, Ronald C W Ma, Takashi Kadowaki, Weiping Jia, Tetsuro Miki, Lu Qi, E Shyong Tai, Karen L Mohlke, Bok-Ghee Han, Yoon Shin Cho, Bong-Jo Kim
• Journal: Diabetes (Diabetes) Vol. 64 Issue 1 Pg. 291-8 (Jan 2015) ISSN: 1939-327X [Electronic] United States
• PMID: 25187374 (Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

Chemical References

• Adaptor Proteins, Signal Transducing
• Blood Glucose
• Cytoskeletal Proteins
• Guanine Nucleotide Exchange Factors
• KANK1 protein, human
• PDK1 protein, human
• Pyruvate Dehydrogenase Acetyl-Transferring Kinase
• RAPGEF4 protein, human
• Tumor Suppressor Proteins
• Receptor, IGF Type 1
• Protein Serine-Threonine Kinases

Topics

• Adaptor Proteins, Signal Transducing
• Adult
• Aged
• Asian People (genetics)
• Blood Glucose (genetics, metabolism)
• Cytoskeletal Proteins
• Asia, Eastern
• Fasting
• Female
• Genetic Variation
• Genome-Wide Association Study
• Genotype
• Guanine Nucleotide Exchange Factors (genetics)
• Humans
• Male
• Middle Aged
• Phenotype
• Protein Serine-Threonine Kinases (genetics)
• Pyruvate Dehydrogenase Acetyl-Transferring Kinase
• Receptor, IGF Type 1 (genetics)
• Tumor Suppressor Proteins (genetics)