Dextran sulfate sodium-induced ulcerative colitis leads to testicular toxicity in mice: Role of inflammation, oxidative stress and DNA damage.

Abstract

Ulcerative colitis is associated with an alteration in gonadal hormones and affects testicular weight in rodents. However, association of ulcerative colitis with testicular damage is not clearly known. Ulcerative colitis was induced using 5% (w/v) dextran sulfate sodium in normal drinking water for 1, 7-day cycle in short-term study and 2.5% (w/v) dextran sulfate sodium in normal drinking water for 4 cycles with 2 weeks remission period between each cycle in long-term study. Ulcerative colitis was associated with a significant increase in inflammation, oxidative stress, DNA damage in testes and sperm DNA damage and a significant decrease in the epididymal sperm count and 3β-HSD expression. No difference was observed in the plasma testosterone levels between control and treatment groups. In the present study, ulcerative colitis was associated with testicular damage, and juvenile mice were found to be more sensitive than adult mice.

• Authors: A R Parmar, P P Trivedi, G B Jena
• Journal: Reproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol) Vol. 49 Pg. 171-84 (Nov 2014) ISSN: 1873-1708 [Electronic] United States
• PMID: 25172807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Interleukin-6
• Tumor Necrosis Factor-alpha
• Testosterone
• Dextran Sulfate
• 3-Hydroxysteroid Dehydrogenases

Topics

• 3-Hydroxysteroid Dehydrogenases (metabolism)
• Animals
• Colitis, Ulcerative (chemically induced, complications)
• DNA Damage (drug effects)
• Dextran Sulfate (adverse effects, toxicity)
• Inflammation (chemically induced)
• Interleukin-6 (analysis)
• Male
• Mice
• Oxidative Stress (drug effects)
• Sperm Count
• Spermatozoa (drug effects)
• Testis (chemistry, drug effects)
• Testosterone (blood)
• Tumor Necrosis Factor-alpha (analysis)