[Vaccines as an approach to the immunocorrection in herpetic infections].

Abstract

Development of vaccines for immunologic correction in herpetic infections is an important problem that raises a growing concern worldwide. The data on the experimental studies of the efficacy of an inactivated whole-virion vaccine against herpes simplex viruses types 1 and 2 (HSV-1 and -2) using an animal model are discussed. The results of the multiyear application of the vaccine to ophthalmology and dermatology practice are also presented. The results unambiguously show a high efficacy of the vaccine in the prevention of recurrences of the infections based on activation of specific T-cell response. A live vaccine against the varicella zoster virus (VZV) was developed for control of the infection in children. For the cytomegalovirus (CMV) infection in adults, inactivated whole-virion vaccines are at the stage of development. An important part of the study addresses a combined application of the inactivated vaccines with immunomodulators.

• Authors: I F Barinskiĭ, L M Alimbarova, A A Lazarenko, F R Makhmudov, O V Sergeev
• Journal: Voprosy virusologii (Vopr Virusol) 2014 Jan-Feb Vol. 59 Issue 1 Pg. 5-11 ISSN: 0507-4088 [Print] Russia (Federation)
• PMID: 25065139 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Herpes Simplex Virus Vaccines

Topics

• Adult
• Animals
• Female
• Herpes Genitalis (immunology, prevention & control)
• Herpes Simplex Virus Vaccines (immunology, therapeutic use)
• Herpesvirus 1, Human (immunology)
• Herpesvirus 2, Human (immunology)
• Humans
• Male