Inactivated Vaccines

Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.

Also Known As:

Networked: 342 relevant articles (45 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cox, Nancy J: 4 articles (05/2014 - 11/2006)
2.	Gendon, Iu Z: 4 articles (03/2009 - 07/2003)
3.	Suarez, David L: 3 articles (04/2015 - 12/2005)
4.	Rappuoli, Rino: 3 articles (01/2015 - 04/2006)
5.	Del Giudice, Giuseppe: 3 articles (01/2015 - 04/2006)
6.	Vellozzi, Claudia: 3 articles (03/2014 - 04/2013)
7.	Barinskiĭ, I F: 3 articles (07/2013 - 11/2002)
8.	Alimbarova, L M: 3 articles (07/2013 - 11/2002)
9.	van den Berg, T: 3 articles (12/2012 - 04/2009)
10.	Tamura, Shin-ichi: 3 articles (08/2010 - 08/2005)

Related Diseases

1.	Infection 11/01/2014 - "Most of the currently available attenuated or inactivated vaccines against this infection are administered intramuscularly and only provide partial protection against the respiratory disease. " 04/26/2013 - "More significantly, active immunization of mice with the inactivated vaccines conferred complete protection against lethal infection with CA16-MAV. " 01/01/1965 - " killed vaccines conferred good protection against intracerebral challenge, but neither live nor killed vaccines administered intraperitoneally protected against oral infection of mice maintained on Freter's regimen. " 11/01/2008 - "Mucosal immunity acquired by natural infection with influenza viruses at the respiratory tract is more effective and cross-protective against subsequent variant virus infection than systemic immunity induced by parenteral immunization with inactivated vaccines. " 09/01/1986 - "Inactivated vaccines of the heterologous ZC113 strain gave better, but still incomplete, protection against A22 challenge infection than did the homologous inactivated vaccine. "
2.	Human Influenza (Influenza) 01/01/2014 - "The overall efficacy of inactivated vaccines in preventing confirmed influenza has a NNV of 71 (95% CI 64 to 80). " 09/01/2013 - "Trivalent inactivated vaccines provided moderate protection against laboratory-confirmed influenza in adults of working age, although VE estimates were sensitive to the model used. " 05/01/2002 - "Review: inactivated vaccines provide the greatest protection against influenza in healthy persons." 03/01/1992 - "[The evaluation of the efficacy of repeated inoculations against influenza using inactivated vaccines]." 02/01/1983 - "[Efficacy of influenza prophylaxis with inactivated vaccines]."
3.	Influenza in Birds (Avian Flu) 05/12/2011 - "Protective efficacy of H5 inactivated vaccines in meat turkey poults after challenge with Egyptian variant highly pathogenic avian influenza H5N1 virus." 10/16/2007 - "In the face of disease outbreaks in poultry and the potential pandemic threat to humans caused by the highly pathogenic avian influenza viruses (HPAIVs) of H5N1 subtype, improvement in biosecurity and the use of inactivated vaccines are two main options for the control of this disease. " 03/01/2009 - "Chitozan is a perspective adjuvant for inactivated vaccines against avian influenza viruses, which could significantly improve immune response and protective efficacy against both homologous and drifted variants of avian influenza viruses A/H5." 02/15/2011 - "Clinical studies have indicated that subvirion inactivated vaccines against avian influenza viruses, particularly H5N1, are poorly immunogenic in humans. " 03/01/2010 - "The aim of this study was to evaluate the level of protection afforded by MDA against challenge with highly pathogenic avian influenza virus (HPAIV), and its suspected interference with current inactivated vaccines in broilers under controlled laboratory conditions. "
4.	Poliomyelitis (Polio) 07/01/1999 - "This is most probably due to the difference in polio vaccination schedules; in Estonia live poliovirus vaccine is used and given at earlier ages than the inactivated vaccines in Finland. " 12/01/1997 - "Oral polio vaccine (OPV) was given between 1963 and 1977 only and recommended simultaneously with inactivated vaccines (DT/DPT) between 1980 and 1985. " 12/01/1989 - "A ten-year experience in control of poliomyelitis through a combination of live and killed vaccines in two developing areas." 05/01/1987 - "An outbreak of poliomyelitis in Finland resulted in the widespread circulation of wild-type 3 poliovirus strains that had antigenic properties distinct from the strains used to produce the attenuated and inactivated vaccines. " 06/01/1986 - "Serological evaluation of poliomyelitis oral and inactivated vaccines in an urban low-income population at Rio de Janeiro, Brazil."
5.	Newcastle Disease 07/01/1986 - "Day-old broilers were administered live and/or inactivated vaccines to assess vaccine efficacy against challenge with Newcastle disease (ND) and infectious bursal disease (IBD). " 10/01/2001 - "It is concluded from the results of this study that fancy chickens can also successfully protected against Newcastle disease by using live and inactivated vaccines which are licensed for hybrid chickens. " 01/01/1988 - "[Production and trials of inactivated vaccines in oil excipient against Newcastle disease in Ethiopia]." 08/01/1994 - "Prophylactic vaccination against Newcastle disease using live and inactivated vaccines, as required by the fowl disease regulations, remains of great importance in maintaining health and productivity of the fowl. " 07/01/1986 - "Vaccination of day-old broiler chicks against Newcastle disease and infectious bursal disease using commercial live and/or inactivated vaccines."

Related Drugs and Biologics

1.	Vaccines
2.	Antibodies
3.	Hemagglutinins (Hemagglutinin)
4.	Neuraminidase (Sialidase)
5.	Formaldehyde (Formol)
6.	Influenza Vaccines (FluMist)
7.	tebufenozide (Mimic)
8.	Attenuated Vaccines
9.	Antiviral Agents (Antivirals)
10.	Neutralizing Antibodies

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Injections
3.	Therapeutics
4.	Intramuscular Injections