Mouse strain variations in the magnitude of induction of liver DT-diaphorase and hereditary transmission of the trait.

Abstract

1. Strain variations among mice in terms of cytosolic DT-diaphorase activity were studied in liver, kidney, stomach and heart tissues with or without the administration of 3-tert-butyl-4-hydroxyanisole (BHA). 2. BHA induced DT-diaphorase activity in all strains examined, and the magnitude of induction varied depending on the strain and tissue. Among the 10 inbred strains tested, BALB/c and C57BL mice showed relatively large magnitudes of induction for liver DT-diaphorase, whereas C3H and CBA mice showed relatively small magnitudes. 3. Results of examinations of BALB/c-C3H-F1, -F2 and C57BL-CBA-F1 mice revealed that smaller magnitudes of induction of liver DT-diaphorase were inherited essentially as a dominant trait. The hereditary trait could be adequately explained by postulating two gene loci that regulate the magnitude of induction. 4. The possible significance of DT-diaphorase activity in chemical carcinogenesis was discussed.

• Authors: S Horie, T Watanabe, Y Sone, K Takayama, H Ikeda, N Takizawa
• Journal: Comparative biochemistry and physiology. B, Comparative biochemistry (Comp Biochem Physiol B) Vol. 93 Issue 2 Pg. 493-8 ( 1989) ISSN: 0305-0491 [Print] England
• PMID: 2505967 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitroso Compounds
• Vitamin K
• Butylated Hydroxyanisole
• 4-nitrosophenol
• NAD(P)H Dehydrogenase (Quinone)
• Quinone Reductases

Topics

• Animals
• Butylated Hydroxyanisole (pharmacology)
• Cytosol (enzymology)
• Enzyme Induction (drug effects)
• Female
• Genetic Variation
• Kidney (enzymology)
• Liver (enzymology)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C3H
• Mice, Inbred CBA
• Myocardium (enzymology)
• NAD(P)H Dehydrogenase (Quinone)
• Nitroso Compounds (metabolism)
• Quinone Reductases (biosynthesis, genetics)
• Stomach (enzymology)
• Vitamin K (metabolism)