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Butylated Hydroxyanisole (BHA)

Subscribe to New Research on Butylated Hydroxyanisole

Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.

Also Known As:

BHA; (1,1-Dimethylethyl)-4-methoxyphenol; AMIF-72; Butyl Methoxyphenol; Embanox; Nipantiox 1-F; Tenox BHA; AMIF 72; AMIF72; Hydroxyanisole, Butylated; Methoxyphenol, Butyl; Nipantiox 1 F; Nipantiox 1F; Butylhydroxyanisole; Phenol, (1,1-dimethylethyl)-4-methoxy-

Networked: 344 relevant articles (13 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Phenols: 309
  - Phenyl Ethers: 4
    - Anisoles
      - Butylated Hydroxyanisole: 344
        3-tert-butyl-4-hydroxyanisole: 6
        2,2'-dihydroxy-3,3'-di-tert-butyl-5,5'-dimethoxydiphenyl: 2
        2-tert-butyl-4-hydroxyanisole: 2
        3-tert-butyl-4,5-dihydroxyanisole: 1
        1-hydroxyl-2-tert-butyl-4-methoxy-6-nitrobenzene
        2,5-di-tert-butyl-4-hydroxyanisole
        3,5-di-tert-butyl-4-hydroxyanisole
        Topanol 354
- Ethers: 174
  - Methyl Ethers: 14
    - Anisoles
      - Butylated Hydroxyanisole: 344
        3-tert-butyl-4-hydroxyanisole: 6
        2,2'-dihydroxy-3,3'-di-tert-butyl-5,5'-dimethoxydiphenyl: 2
        2-tert-butyl-4-hydroxyanisole: 2
        3-tert-butyl-4,5-dihydroxyanisole: 1
        1-hydroxyl-2-tert-butyl-4-methoxy-6-nitrobenzene
        2,5-di-tert-butyl-4-hydroxyanisole
        3,5-di-tert-butyl-4-hydroxyanisole
        Topanol 354
  - Phenyl Ethers: 4
    - Anisoles
      - Butylated Hydroxyanisole: 344
        3-tert-butyl-4-hydroxyanisole: 6
        2,2'-dihydroxy-3,3'-di-tert-butyl-5,5'-dimethoxydiphenyl: 2
        2-tert-butyl-4-hydroxyanisole: 2
        3-tert-butyl-4,5-dihydroxyanisole: 1
        1-hydroxyl-2-tert-butyl-4-methoxy-6-nitrobenzene
        2,5-di-tert-butyl-4-hydroxyanisole
        3,5-di-tert-butyl-4-hydroxyanisole
        Topanol 354

Experts

1.	Fujisawa, Seiichiro: 7 articles (03/2015 - 08/2002)
2.	Sharma, Veena: 4 articles (04/2014 - 01/2011)
3.	Yokoe, Ichiro: 4 articles (05/2008 - 09/2004)
4.	Murakami, Yukio: 3 articles (03/2015 - 05/2006)
5.	Kadoma, Yoshinori: 3 articles (05/2008 - 08/2002)
6.	Fernández, C: 3 articles (05/2006 - 04/2001)
7.	Aller, P: 3 articles (05/2006 - 04/2001)
8.	de Blas, E: 3 articles (05/2006 - 04/2001)
9.	Makino, Toshihiko: 2 articles (08/2015 - 04/2008)
10.	Brutsaert, Tom D: 2 articles (03/2015 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2011 - "In this study, the authors investigated the effects of BHA on the growth inhibition and death of HeLa cervical cancer cells. " 05/01/2007 - "Most in vitro studies describing the effects of BHA have been performed in cancer cells, but it is unclear whether normal cells are equally susceptible to BHA exposure. " 06/01/1995 - "The neoplasms occurred in 51 of 204 fish (25%) used in a carcinogenicity study of butylated hydroxyanisole fed in a lyophilized chicken liver diet for up to 9 months. " 07/01/2013 - "More importantly, the continuous administration of the ROS inhibitor BHA efficiently blocked the occurrence of TAMs and markedly suppressed tumorigenesis in mouse cancer models. " 03/01/2011 - "Butylated hydroxyanisole inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis and GSH depletion."
2.	Papilloma (Papillomatosis) 09/01/1988 - "These results showed that the diet alone was not the reason for the failure of BHA to induce forestomach papilloma in the LVG hamsters. " 12/01/1986 - "Papillomas of the forestomach developed in 20 and 100% of the rats given diets containing 1 and 2% BHA, respectively. " 11/01/1986 - "In mice, papillomas were induced by BHA in both BHA-treated groups after more than 88 weeks. " 11/01/1986 - "In hamsters, papillomas appeared in week 8 in both BHA-treated groups, and in both groups, the incidence of papillomas was much higher than in BHA-treated rats. " 11/01/1986 - "In rats, papillomas first appeared in week 8 in the group given the higher level of BHA and in week 56 in that given the lower level. "
3.	Carcinoma (Carcinomatosis) 08/01/1993 - "With SO, only marginal morphological changes were occasionally observed, despite the fact that the respective long-term treatment had been reported to result in a higher carcinoma incidence than treatment with BHA. " 12/30/1988 - "The results showed that except for carcinomas and some epithelial downgrowths, cellular proliferation, measured by radioautography in the epithelium lining the greater and the lesser curvature of the forestomach, remained dependent on the continuous presence of 2% BHA for, at least, 12 months. " 11/01/1986 - "Although the incidence was not statistically significant, carcinoma was also seen in mice, suggesting that BHA may also be carcinogenic to mouse forestomach." 02/01/1986 - "In intact rats forestomach carcinomas were seen by other investigators after feeding 2% BHA for 15-20 months. " 12/02/1993 - "However, IM in combination with either BHA or Na-AsA significantly reduced both the incidence and the multiplicity of papillomas and carcinomas as compared with the values of groups receiving BHA or Na-AsA alone. "
4.	Poisoning 11/01/1982 - "Treatment of sheep with EQ (2.5 g/sheep/day for 9 days before poisoning) gave significant protection from toxic doses of bitterweed, but the protective effect of BHA was insignificant. " 08/01/1981 - "Protective effect of butylated hydroxyanisole on acute hymenoxon and bitterweed poisoning." 01/01/1984 - "In a chronic feeding trial with tansy ragwort, a combination of BHA and cysteine increased (P less than .05) the survival times of rats, showing protective activity against PA poisoning. " 05/01/1982 - "Protective effects of butylated hydroxyanisole, ethoxyquin, and disulfiram on acute pyrrolizidine alkaloids poisoning in mice."
5.	Anoxia (Hypoxia) 11/01/2001 - "alpha-TOC, BHA, DTBHA and beta-TAG improved significantly the response of the strips to electrical field stimulation either during the anoxia-glucopenia phase or thereafter when recovering during reperfusion, as compared to untreated tissues. " 01/01/2008 - "The subject participants comprised two different study groups including BLA subjects (born at low altitude) who were lifelong sea-level residents transiently exposed to hypobaric hypoxia (<24 h) and BHA subjects (born at HA) who were lifelong residents of HA. " 03/01/2015 - "BHA had a significantly higher VO2peak at hypoxia (40.31 ± 1.0 ml/min/kg) as compared to BSL (35.78 ± 0.96 ml/min/kg, P = 0.001), adjusting for sex. " 03/01/2015 - "Male and female volunteers were recruited in Lima, Peru (150 m), and were divided in two groups, based on their developmental exposure to hypoxia, those: a) Born at sea-level individuals (BSL), with no developmental exposure to hypoxia (n = 34) and b) Born at high-altitude individuals (BHA) with full developmental exposure to hypoxia (n = 32), but who migrated to sea-level as adults (>16-years-old). " 11/01/2001 - "2-t-butyl-4-methoxyphenol (BHA), 3,5-di-t-butyl-hydroxyanisole (DTBHA), 2,6-diisopropylphenol (propofol), alpha-tocopherol (alpha-TOC) and two newly synthesised analogues of BHA, namely 1-O-(4-hydroxy-3-t-butyl)phenyl-2,3,4,6-tetra-O-acetyl-beta-D-glucopyranose (beta-TAG) and 1-O-(4-hydroxy-3-t-butyl)phenyl-beta-D-glucopyranose (beta-GLU), were tested for their capability to protect the intrinsic nerves of guinea-pig urinary bladder from damage due to anoxia-glucopenia and re-exposure to glucose and O2. "

Related Drugs and Biologics

1.	Butylated Hydroxyanisole (BHA)
2.	Enzymes
3.	Disulfiram (Antabuse)
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Butylated Hydroxytoluene (BHT)
6.	Antioxidants
7.	allyl sulfide
8.	Ethoxyquin
9.	Acetylcysteine (Siran)
10.	Dehydroepiandrosterone (DHEA)

Related Therapies and Procedures

1.	Chemoprevention
2.	Injections
3.	Microspheres (Microsphere)
4.	Arthroplasty
5.	Hepatectomy