Strontium chloride: can it be a new treatment option for ulcerative colitis?

Abstract

BACKGROUND/AIMS:

Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap and can be given orally. We for the first time aimed to investigate the effect of strontium chloride (SrCl2) on inflammation in experimental colitis.

METHODS:

Thirty female Wistar albino rats were divided into 5 groups each containing 6 rats. The rats in groups 1 and 2 served as the healthy control and colitis group, respectively. The rats in groups 3, 4, and 5 had colitis and received 40 mg/kg SrCl2, 160 mg/kg SrCl2, and 1 mg/kg prednisolone by oral gavage, respectively. The rats were sacrificed for histological evaluation and determination of serum neopterin, TNF-α, and IFN-γ levels.

RESULTS:

The neopterin, TNF-α and IFNγ levels of group 2 was significantly higher than the other groups. The neopterin, TNF-α, and IFN-γ levels of controls and other treatment groups were comparable. There were a significant difference in macroscopic and microscopic healing between group 2 and other groups histologically. But there was not a significant difference within treatment receiving groups.

CONCLUSION:

SrCl2 had comparable therapeutic efficiency with prednisolone.

• Authors: Firdevs Topal, Ozlem Yonem, Nevin Tuzcu, Mehmet Tuzcu, Hilmi Ataseven, Melih Akyol
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 530687 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 25032214 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• NF-kappa B
• Tumor Necrosis Factor-alpha
• Neopterin
• Interferon-gamma
• Prednisolone
• strontium chloride
• Strontium

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Colitis, Ulcerative (blood, drug therapy, pathology)
• Disease Models, Animal
• Female
• Interferon-gamma (blood)
• NF-kappa B (metabolism)
• Neopterin (blood)
• Prednisolone (pharmacology)
• Rats
• Rats, Wistar
• Strontium (pharmacology)
• Tumor Necrosis Factor-alpha (blood)