Abstract | CONTEXT:
Hypoxia injury (HI) with its long-term neurological complications is one of the leading causes of morbidity and mortality in the world. Currently, the treatment regimens for hypoxia are aimed only at ameliorating the damage without complete cure. The need, therefore, for novel therapeutic drugs to treat HI continues. OBJECTIVE: MATERIALS AND METHODS: RESULTS: EECR at doses of 200 and 400 mg/kg was able to protect against the cognitive impairments, and the locomotor activity and muscular coordination defects, which are affected by sodium nitrite-induced hypoxia injury in rats. CONCLUSION: Based on our results, we suggest that the medicinal herb C. rotundus possesses a protective effect against sodium nitrite-induced hypoxia in rats. Further studies on these protective effects of EECR may help in designing better therapeutic regimes for hypoxia injury.
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Authors | Dhas Jebasingh, Dhas Devavaram Jackson, S Venkataraman, Ernest Adeghate, Bright Starling Emerald |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 52
Issue 12
Pg. 1558-69
(Dec 2014)
ISSN: 1744-5116 [Electronic] England |
PMID | 25026346
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Plant Extracts
- Galantamine
- Pyrithioxin
- Sodium Nitrite
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Topics |
- Animals
- Behavior, Animal
(drug effects)
- Cognition Disorders
(etiology, prevention & control)
- Cyperus
(chemistry)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Galantamine
(pharmacology)
- Hypoxia
(complications, drug therapy)
- Male
- Medicine, Ayurvedic
- Motor Activity
(drug effects)
- Plant Extracts
(administration & dosage, pharmacology)
- Pyrithioxin
(pharmacology)
- Rats
- Rats, Wistar
- Sodium Nitrite
(toxicity)
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