Genome wide association scan for chronic periodontitis implicates novel locus.

Abstract

BACKGROUND:

There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).

METHODS:

Genotypingi of over half-million single nucleotide polymorphisms was determined. Analyses were done twice, first in the complete dataset of all ethnicities, and second including only samples defined as self-reported Whites. From the top 100 results, twenty single nucleotide polymorphisms had consistent results in both analyses (borderline p-values ranging from 1E-05 to 1E-6) and were selected to be tested in two independent datasets derived from 1,460 individuals from Porto Alegre, and 359 from Rio de Janeiro, Brazil. Meta-analyses of the Single nucleotide polymorphisms showing a trend for association in the independent dataset were performed.

RESULTS:

The rs1477403 marker located on 16q22.3 showed suggestive association in the discovery phase and in the Porto Alegre dataset (p = 0.05). The meta-analysis suggested the less common allele decreases the risk of chronic periodontitis.

CONCLUSIONS:

Our data offer a clear hypothesis to be independently tested regarding the contribution of the 16q22.3 locus to chronic periodontitis.

• Authors: Ping Feng, Xiaojing Wang, Priscila L Casado, Erika C Küchler, Kathleen Deeley, Jacqueline Noel, Hyongsup Kimm, Ji-Hye Kim, Alex N Haas, Valquiria Quinelato, Leticia L Bonato, Jose M Granjeiro, Cristiano Susin, Alexandre R Vieira
• Journal: BMC oral health (BMC Oral Health) Vol. 14 Pg. 84 (Jul 09 2014) ISSN: 1472-6831 [Electronic] England
• PMID: 25008200 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Genetic Markers

Topics

• Adult
• Aged
• Aged, 80 and over
• Alleles
• Chromosome Mapping
• Chromosomes, Human, Pair 16 (genetics)
• Chromosomes, Human, Pair 21 (genetics)
• Chronic Periodontitis (ethnology, genetics)
• Diabetes Complications
• Ethnicity (genetics)
• Female
• Gene Frequency (genetics)
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (genetics)
• Genetic Variation (genetics)
• Genome-Wide Association Study
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors
• Smoking
• White People (genetics)