Terahertz pulsed spectroscopy of paraffin-embedded brain glioma.

Abstract

The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.

• Authors: Kun Meng, Tu-nan Chen, Tao Chen, Li-guo Zhu, Qiao Liu, Zhao Li, Fei Li, Sen-cheng Zhong, Ze-ren Li, Hua Feng, Jian-heng Zhao
• Journal: Journal of biomedical optics (J Biomed Opt) Vol. 19 Issue 7 Pg. 077001 ( 2014) ISSN: 1560-2281 [Electronic] United States
• PMID: 25003757 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Brain Neoplasms (chemistry)
• Cell Line, Tumor
• Diagnostic Imaging (instrumentation, methods)
• Equipment Design
• Glioma (chemistry)
• Male
• Mice
• Mice, Inbred C57BL
• Paraffin Embedding
• Refractometry
• Terahertz Spectroscopy (instrumentation, methods)