Abstract | IMPORTANCE: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of administrative claims data for Medicare beneficiaries aged at least 65 years hospitalized for traumatic brain injury during 2006 through 2009 who received warfarin in the month prior to injury (n = 10,782). INTERVENTION: MAIN OUTCOMES AND MEASURES: RESULTS: Medicare beneficiaries with traumatic brain injury were predominantly female (64%) and white (92%), with a mean (SD) age of 81.3 (7.3) years, and 82% had atrial fibrillation. Over the 12 months following hospital discharge, 55% received warfarin during 1 or more 30-day periods. We examined the lagged effect of warfarin use on outcomes in the following period. Warfarin use in the prior period was associated with decreased risk of thrombotic events (relative risk [RR], 0.77 [95% CI, 0.67-0.88]) and increased risk of hemorrhagic events (RR, 1.51 [95% CI, 1.29-1.78]). Warfarin use in the prior period was associated with decreased risk of hemorrhagic or ischemic stroke (RR, 0.83 [95% CI, 0.72-0.96]). CONCLUSIONS AND RELEVANCE:
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Authors | Jennifer S Albrecht, Xinggang Liu, Mona Baumgarten, Patricia Langenberg, Gail B Rattinger, Gordon S Smith, Steven R Gambert, Stephen S Gottlieb, Ilene H Zuckerman |
Journal | JAMA internal medicine
(JAMA Intern Med)
Vol. 174
Issue 8
Pg. 1244-51
(Aug 2014)
ISSN: 2168-6114 [Electronic] United States |
PMID | 24915005
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Adrenal Gland Diseases
(chemically induced)
- Aged
- Aged, 80 and over
- Anticoagulants
(adverse effects)
- Atrial Fibrillation
(complications, drug therapy)
- Brain Injuries
(complications)
- Brain Ischemia
(etiology, prevention & control)
- Female
- Gastrointestinal Hemorrhage
(chemically induced)
- Hemorrhage
(chemically induced)
- Humans
- Intracranial Hemorrhages
(chemically induced)
- Male
- Myocardial Infarction
(etiology, prevention & control)
- Pulmonary Embolism
(etiology, prevention & control)
- Retrospective Studies
- Risk Assessment
- Stroke
(etiology, prevention & control)
- Thrombosis
(prevention & control)
- Venous Thrombosis
(etiology, prevention & control)
- Warfarin
(adverse effects)
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