Abstract | OBJECTIVE: METHODS: We conducted a systematic literature search from the years 1990-2013, resulting in identification of 903 articles. In order to investigate whether intima-media thickness (IMT) is different in children with and without FH, we conducted a meta-analysis of the studies comparing FH children with a control group. RESULTS: 37 original articles were included. Among these, 24 reported subclinical measurements, whereas other articles reported measurements of atherogenic lipids (n = 9), inflammatory markers (n = 10), hemostatic markers (n = 6) and other surrogate markers of atherosclerosis (n = 7). In the meta-analysis (n = 8), IMT was significantly thicker in children with FH than in control children (weighted mean difference 0.06, 95% confidence interval [0.01, 0.11]). CONCLUSION: Elevated LDL-cholesterol distinguishes children with and without FH, but these groups of children also differ in several other ways. In particular, children with FH display a variety of changes reflecting both the lipid and the inflammatory arm of atherosclerosis. The IMT-meta-analysis result strengthens the evidence of early atherosclerotic development in children with FH. In a clinical perspective, early diagnosing and treatment of children with FH is of high importance to attenuate development of the potential ongoing early atherosclerotic process in these individuals.
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Authors | Ingunn Narverud, Kjetil Retterstøl, Per Ole Iversen, Bente Halvorsen, Thor Ueland, Stine M Ulven, Leiv Ose, Pål Aukrust, Marit B Veierød, Kirsten B Holven |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 235
Issue 2
Pg. 299-309
(Aug 2014)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 24908240
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Cholesterol, LDL
- Lipoprotein(a)
- Lipoproteins, LDL
- oxidized low density lipoprotein
- C-Reactive Protein
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Topics |
- Adolescent
- Atherosclerosis
(etiology)
- C-Reactive Protein
(metabolism)
- Carotid Intima-Media Thickness
- Child
- Child, Preschool
- Cholesterol, LDL
(blood)
- Endothelium, Vascular
(physiopathology)
- Humans
- Hyperemia
(complications)
- Hyperlipoproteinemia Type II
(complications)
- Infant
- Infant, Newborn
- Leukocytes, Mononuclear
(metabolism)
- Lipoprotein(a)
(blood)
- Lipoproteins, LDL
(blood)
- Regional Blood Flow
- Vasodilation
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