Serum apolipoprotein B-48 concentration is associated with a reduced estimated glomerular filtration rate and increased proteinuria.

Abstract

AIM:

Apolipoprotein B-48 (apoB-48) is a constituent of chylomicrons and their remnants (chylomicron remnants). A high concentration of serum apoB-48 is suspected to be a major risk factor for the development of atherosclerotic cardiovascular disease. Proteinuria and a reduced estimated glomerular filtration rate (eGFR) are independent risk factors for cardiovascular events and renal dysfunction. In the present study, we examined whether the serum apoB-48 concentration is associated with renal dysfunction.

METHODS:

A total of 264 patients was enrolled and classified into four groups according to the eGFR and level of proteinuria: a high eGFR (＞60mL/min/1.73m(2)) without proteinuria (≥1＋ by urine dipstick) (n=50); a high eGFR with proteinuria (n=75); a low eGFR (＞60mL/min/1.73m(2)) without proteinuria (n=74); and a low eGFR with proteinuria (n=65). Biochemical markers of lipid metabolism, including the fasting serum apoB-48 concentration, were compared between the four groups.

RESULTS:

The serum log-apoB-48 and log-apoB-48/TG levels were significantly higher in the patients with a high eGFR with proteinuria, low eGFR with proteinuria and low eGFR without proteinuria than in those with a high eGFR without proteinuria, with the most significant differences for these parameters. The eGFR was found to be significantly correlated with the log-apoB-48 and log-apoB-48/TG levels, whereas urinary protein was found to be significantly correlated with the log-apoB-48 level only. A multiple regression analysis indicated that the log-apoB-48/TG level was a significant determinant of a reduced eGFR.

CONCLUSIONS:

Both a low eGFR (＜60) and proteinuria (≥1＋) are independent determinants of a high apoB-48 concentration. Taken together, the present results suggest that an increased serum apoB-48 concentration contributes to an increased risk of cardiovascular events.

• Authors: Manabu Okubo, Hiroyuki Hanada, Masahiko Matsui, Yoh Hidaka, Daisaku Masuda, Yasushi Sakata, Shizuya Yamashita
• Journal: Journal of atherosclerosis and thrombosis (J Atheroscler Thromb) Vol. 21 Issue 9 Pg. 974-82 ( 2014) ISSN: 1880-3873 [Electronic] Japan
• PMID: 24882621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoprotein B-48
• Biomarkers

Topics

• Aged
• Apolipoprotein B-48 (blood)
• Biomarkers (metabolism)
• Female
• Glomerular Filtration Rate
• Humans
• Kidney Diseases (complications, physiopathology)
• Kidney Function Tests
• Male
• Middle Aged
• Prognosis
• Proteinuria (blood, diagnosis, etiology)
• Risk Factors