Abstract | BACKGROUND: METHODS: Thirty GCC patients were randomly assigned to resistance training ( resistance training group (INT), n=15) or usual care (CON, n=15) during 9 weeks of BEP therapy. Resistance training consisted of thrice weekly sessions of four exercises, 3-4 sets/exercise of 10-15 repetitions at 12-15 repetition maximum load. The primary endpoint was muscle fibre size, assessed in muscle biopsies from musculus vastus lateralis. Secondary endpoints were fibre phenotype composition, body composition, strength, blood biochemistry and patient-reported endpoints. Healthy age-matched subjects (REF, n=19) performed the same RT-programme for comparison purposes. RESULTS: Muscle fibre size decreased by -322 μm(2) (95% confidence interval (CI): -899 to 255; P=0.473) in the CON-group and increased by +206 μm(2) (95% CI: -384 to 796; P=0.257) in the INT-group (adjusted mean difference (AMD), +625 μm(2), 95% CI: -253 to 1503, P=0.149). Mean differences in type II fibre size (AMD, +823 μm(2), P=0.09) and lean mass (AMD, +1.49 kg, P=0.07) in favour of the INT-group approached significance. The REF-group improved all muscular endpoints and had significantly superior changes compared with the INT-group (P<0.05). CONCLUSIONS: BEP was associated with significant reduction in lean mass and strength and trends toward unfavourable changes in muscle fibre size and phenotype composition. Resistance training was safe and attenuated dysfunction in selected endpoints, but BEP blunted several positive adaptations observed in healthy controls. Thus, our study does not support the general application of resistance training in this setting but larger-scaled trials are required to confirm this finding.
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Authors | J F Christensen, L W Jones, A Tolver, L W Jørgensen, J L Andersen, L Adamsen, P Højman, R H Nielsen, M Rørth, G Daugaard |
Journal | British journal of cancer
(Br J Cancer)
Vol. 111
Issue 1
Pg. 8-16
(Jul 08 2014)
ISSN: 1532-1827 [Electronic] England |
PMID | 24867693
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bleomycin
- Etoposide
- Cisplatin
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Bleomycin
(administration & dosage, adverse effects)
- Cisplatin
(administration & dosage, adverse effects)
- Combined Modality Therapy
- Etoposide
(administration & dosage, adverse effects)
- Humans
- Male
- Muscle, Skeletal
(drug effects, physiopathology)
- Neoplasms, Germ Cell and Embryonal
(drug therapy, physiopathology, therapy)
- Prospective Studies
- Resistance Training
(adverse effects, methods)
- Single-Blind Method
- Testicular Neoplasms
(drug therapy, physiopathology, therapy)
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