Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice.

Abstract

The nuclear hormone receptors liver X receptor α (LXRα) and peroxisome proliferator-activated receptor γ (PPARγ) play key roles in the development of fatty liver. To determine the link between hepatic PPARγ and LXRα signaling and the development of fatty liver, a LXRα-specific ligand, T0901317, was administered to normal OB/OB and genetically obese (ob/ob) mice lacking hepatic PPARγ (Pparγ(ΔH)). In ob/ob-Pparγ(ΔH) and OB/OB-Pparγ(ΔH) mice, as well as ob/ob-Pparγ(WT) and OB/OB-Pparγ(WT) mice, the liver weights and hepatic triglyceride levels were markedly increased in response to T0901317 treatment. These results suggest that hepatic PPARγ and LXRα signals independently contribute to the development of fatty liver.

• Authors: Kimihiko Matsusue, Daisuke Aibara, Risa Hayafuchi, Kohei Matsuo, Soichi Takiguchi, Frank J Gonzalez, Shigeru Yamano
• Journal: FEBS letters (FEBS Lett) Vol. 588 Issue 14 Pg. 2277-81 (Jun 27 2014) ISSN: 1873-3468 [Electronic] England
• PMID: 24857376 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Federation of European Biochemical Societies. All rights reserved.

Chemical References

• Anticholesteremic Agents
• Blood Glucose
• Hydrocarbons, Fluorinated
• Hypoglycemic Agents
• Liver X Receptors
• Nr1h3 protein, mouse
• Orphan Nuclear Receptors
• PPAR gamma
• Sulfonamides
• T0901317

Topics

• Animals
• Anticholesteremic Agents (pharmacology)
• Blood Glucose
• Fatty Liver (metabolism)
• Hydrocarbons, Fluorinated (pharmacology)
• Hypoglycemic Agents (pharmacology)
• Lipogenesis
• Liver (metabolism, pathology)
• Liver X Receptors
• Mice
• Mice, Knockout
• Mice, Obese
• Orphan Nuclear Receptors (agonists, physiology)
• PPAR gamma (physiology)
• Sulfonamides (pharmacology)