We investigated the difference in the influence on 10 allergic factors of 3
anti-allergic drugs:
azelastine,
tranilast,
ketotifen. We determined the ranking of 10 allergic factors using the relative range ratio calculated by Multiple factor analysis. The ranking as follows: (1) Eosinophil count (2)
IgE RAST score to H.D. (3)
IgG4 antibody titers to egg white (4)
IgE RAST score to egg white (5)
IgE RAST score to D.f. (6)
IgG4 antibody titers to milk (7)
IgE RIST (8)
IgG4 antibody titers to soybean (9)
IgE RAST score to soybean (10)
IgE RAST score to milk. Then we split 122 asthmatic children (mean age: 9.3) into 3 groups and gave each group a different one of the 3
anti-allergic drugs for one year. From daily records of
asthma attacks and clinical findings, we classified the children into improved and not-improved groups within their respective
anti-allergic drug group, and we investigated the changes in and the change ratios of the 10 allergic factors by the Student t method over this one year. The results were as follows. 1) There was no difference in the chang of 3 allergic factors (Eosinophil count,
IgG4 antibody titers to egg white and
IgE RIST) among the 3
anti-allergic drug treated groups. 2) The specific
IgE antibodies to H.D. and D.f. had a remarkable decline tendency in treated groups by
azelastine and
tranilast. 3) The specific
IgE antibody to egg white had a remarkable decline tendency in treated group by
ketotifen.