Aliphatic phenolic ethers from Trichobotrys effusa.

Abstract

Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).

• Authors: Jih-Jung Chen, Shih-Wei Wang, Hui-Yun Hsiao, Ming-Shian Lee, Yu-Min Ju, Yueh-Hsiung Kuo, Tzong-Huei Lee
• Journal: Journal of natural products (J Nat Prod) Vol. 77 Issue 5 Pg. 1097-101 (May 23 2014) ISSN: 1520-6025 [Electronic] United States
• PMID: 24797798 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ethers
• Macrolides
• Phenols
• monorden
• Fluorouracil

Topics

• Ascomycota (chemistry)
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Ethers (chemistry, isolation & purification, pharmacology)
• Fluorouracil (pharmacology)
• Humans
• Macrolides (pharmacology)
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Phenols (chemistry, isolation & purification, pharmacology)