[Treatment of tubal pregnancy with prostaglandins: a multicenter study].

Abstract	In this prospective multi-centre-study, the new treatment of tubal pregnancies by means of local prostaglandin (PG) F2 alpha and systemic PG E2 application was compared to the usual surgical technique of eliminating the conceptus. In 71 patients treated with PG, the method proved to be successful in 81%; 21 patients (19%) required surgical intervention later. With an initial beta-hCG level of 2500 mIE/ml, the success rate increased to 88%. The duration of hospitalisation was significantly reduced in the PG group compared to the patients treated by primary operation (3 +/- 1 versus 6 +/- 2 days). In the PG-group, only 2 of 24 hysterosalpingograms showed tubal occlusions after treatment, whereas occlusion was present in 3 of 8 patients of the surgically treated group. Four subsequent intrauterine pregnancies in the PG-group occurred compared to none in the surgical group. PG treatment of tubal pregnancy in patients with a low initial beta-hCG value (less than 2500 mIE/ml) revealed promising results with regard to reduced postoperative morbidity and future fertility.
Authors	C Egarter, R Fitz, J Spona, W Grünberger, P Wagenbichler, R Haidbauer, K Baumgarten, A Beck, S Leodolter, H Kiss
Journal	Geburtshilfe und Frauenheilkunde (Geburtshilfe Frauenheilkd) Vol. 49 Issue 9 Pg. 808-12 (Sep 1989) ISSN: 0016-5751 [Print] Germany
Vernacular Title	Behandlung der Eileiterschwangerschaft mit Prostaglandinen: eine Multizenterstudie.
PMID	2478415 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References	Abortifacient Agents Abortifacient Agents, Nonsteroidal Chorionic Gonadotropin Chorionic Gonadotropin, beta Subunit, Human Peptide Fragments sulprostone Dinoprost Dinoprostone
Topics	Abortifacient Agents (administration & dosage) Abortifacient Agents, Nonsteroidal (administration & dosage) Chorionic Gonadotropin (blood) Chorionic Gonadotropin, beta Subunit, Human Clinical Trials as Topic Dinoprost (administration & dosage) Dinoprostone (administration & dosage) Drug Therapy, Combination Female Humans Injections, Intralesional Injections, Intramuscular Laparoscopy Peptide Fragments (blood) Pregnancy Pregnancy, Tubal (drug therapy) Prospective Studies

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