Single-institution outcomes in the first year of pancreas transplantation from brain-dead donors.

Abstract

BACKGROUND:

Under a revision to the law in 2010, the number of pancreas transplantations from brain-dead donors has been increasing in Japan. We started a new Pancreatic Transplant Program at Fujita Health University Hospital in September 2012.

METHODS:

A total of 11 cases of pancreas transplantation from brain-dead donors performed at Fujita Health University Hospital were analyzed in terms of the background characteristics of the donors and recipients and the outcomes.

RESULTS:

The mean age of the recipients was 45.2 years, and all recipients had a long-term history of diabetes (mean: 32.5 years). In the simultaneous pancreas and kidney transplantation (SPK) cases, the patients also had a long history of hemodialysis (mean: 8.0 years). Although the average donor age was 42.5 years, 90% of the donors were marginal donors, defined according to the following factors: (1) >45 years old, (2) death from cardiovascular disease, (3) episodes of cardiac arrest, (4) use of high doses of catecholamines. The pancreatic graft survival rate was 100%, although 1 patient required a small amount of insulin to maintain euglycemia. In addition, the kidney graft survival rate was also 100% in the SPK cases.

CONCLUSIONS:

The new Pancreatic Transplant Program at Fujita Health University has provided excellent outcomes for type 1 diabetic patients.

• Authors: T Ito, T Kenmochi, A Suzuki, M Maruyama, M Kusaka, H Sasaki, T Asano, H Matsubara, K Hoshinaga
• Journal: Transplantation proceedings (Transplant Proc) Vol. 46 Issue 3 Pg. 970-2 (Apr 2014) ISSN: 1873-2623 [Electronic] United States
• PMID: 24767393 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Brain Death
• Female
• Humans
• Male
• Middle Aged
• Pancreas Transplantation
• Tissue Donors
• Treatment Outcome