Abstract | INTRODUCTION: MATERIALS AND METHODS: Male Wistar albino rats weighing 150-200 g (10-12 weeks old) were used. Animals were divided into four groups. Group 1 served as control group and received normal saline, group 2 served as toxic group and received 2 mg/kg tacrolimus i.p., group 3 served as treatment group and received 2 mg/kg tacrolimus i.p. followed by 2 mg/kg aliskiren orally and group 4 served as drug per se group and received 2 mg/kg aliskiren orally. Tacrolimus-induced nephrotoxicity was assessed biochemically and histopathologically. RESULTS: CONCLUSION:
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Authors | Naif O Al-Harbi, Faisal Imam, Mohammed M Al-Harbi, Muzaffar Iqbal, Ahmed Nadeem, Othman A Al-Shahrah, Hesham M Korashy, Khalid A Al-Hosaini, Mukhtar Ahmed, Saleh Bahashwar |
Journal | Journal of the renin-angiotensin-aldosterone system : JRAAS
(J Renin Angiotensin Aldosterone Syst)
Vol. 16
Issue 4
Pg. 1329-36
(Dec 2015)
ISSN: 1752-8976 [Electronic] England |
PMID | 24737642
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2014. |
Chemical References |
- Amides
- Fumarates
- aliskiren
- Catalase
- Glutathione
- Tacrolimus
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Topics |
- Amides
(pharmacology, therapeutic use)
- Animals
- Catalase
(metabolism)
- Fumarates
(pharmacology, therapeutic use)
- Glutathione
(metabolism)
- Kidney
(drug effects, pathology, physiopathology, ultrastructure)
- Kidney Diseases
(blood, chemically induced, drug therapy, physiopathology)
- Lipid Peroxidation
(drug effects)
- Male
- Oxidative Stress
(drug effects)
- Rats, Wistar
- Tacrolimus
(adverse effects)
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