Corticosteroid therapy was effective in controlling refractory coronary vasospasms complicated by hypereosinophilia.

Abstract

A 48-year-old man suffered from uncontrollable coronary vasospasms, even when taking the maximum dose of vasodilators. The patient had a history of hypereosinophilia, and as the eosinophilia worsened, more frequent and intense coronary spastic angina (CSA) attacks occurred. He was treated with 20 mg/day of oral prednisolone, and the chest symptoms of CSA completely resolved thereafter. We encountered a refractory CSA patient with an allergic predisposition for which the oral administration of corticosteroids was markedly effective. Although the priority of corticosteroid therapy is not clinically high in patients with CSA, it can be effective especially in patients with an allergic background.

• Authors: Tetsuya Nomura, Natsuya Keira, Shunta Taminishi, Hiroshi Kubota, Yusuke Higuchi, Sho Ikegame, Kensuke Terada, Taku Kato, Yota Urakabe, Tetsuya Tatsumi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 7 Pg. 735-8 ( 2014) ISSN: 1349-7235 [Electronic] Japan
• PMID: 24694487 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Prednisolone

Topics

• Coronary Vasospasm (complications, drug therapy, physiopathology)
• Electrocardiography
• Eosinophilia (complications, diagnosis, drug therapy)
• Follow-Up Studies
• Glucocorticoids (therapeutic use)
• Humans
• Male
• Middle Aged
• Prednisolone (therapeutic use)