Lectin-binding sites in squamous cell carcinomas and keratoacanthomas.

Abstract

The lectin-binding pattern of malignant and benign human epidermal tumours was studied. Twelve squamous cell carcinomas and ten kerato-acanthomas were investigated, using fluorochrome-conjugated lectins. Lectins used were Canavalia ensiformis agglutinin (Con-A), Helix pomatia agglutinin (HPA), Phaseolus vulgaris agglutinin (PHA-L), and Ricinus communis agglutinin (RCA-120). Two types of fluorescence pattern, Intercellular 'Pemphigus-like' and Peritumoral, were noted. Both allowed classification of these tumours on the basis of their lectin-binding reactivity. Moreover, the expression of receptors for these lectins made it possible to distinguish between low-grade and well-differentiated squamous cell carcinomas.

• Authors: A Ramírez-Bosca, A Reano, F Valcuende-Cavero, J Thivolet, A Castells-Rodellas
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 68 Issue 6 Pg. 480-5 ( 1988) ISSN: 0001-5555 [Print] Sweden
• PMID: 2467485 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Lectins

Topics

• Binding Sites
• Carcinoma, Squamous Cell (metabolism, pathology)
• Humans
• Keratoacanthoma (metabolism, pathology)
• Lectins (metabolism)
• Skin Neoplasms (pathology)