Abstract | BACKGROUND: OBJECTIVE: METHODS: This open-label clinical study was conducted at the Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran. Clarithromycin and acetylcysteine were administered concomitantly for 6 months to male SM-exposed patients with chronic bronchitis and bronchiolitis obliterans who were nonresponsive to conventional treatments. Efficacy analysis included symptom assessment and pulmonary function tests (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], and FEV1/FVC ratio) using spirometry, performed at baseline and after 2 and 6 months of treatment. RESULTS: Seventeen male patients (mean [SD] age, 38.3 [5.3] years [range, 31-50 years]; mean [SD] body weight, 77.9 [15.7] kg) were included in the study. Cough and sputum production were each found in 10 of 17 patients (58.8%) at baseline and were improved in all 10 patients after the administration of clarithromycin and acetylcysteine. FEV1 and FVC also were improved, by mean (SD) 10.6% (9.7%) (P < 0.001 vs baseline) and 12.9% (13.6%) (P = 0.001 vs baseline). No significant change in FEV1/FVC ratio was found. CONCLUSIONS:
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Authors | Mostafa Ghanei, Kamran Abolmaali, Jafar Aslani |
Journal | Current therapeutic research, clinical and experimental
(Curr Ther Res Clin Exp)
Vol. 65
Issue 6
Pg. 495-504
(Nov 2004)
ISSN: 0011-393X [Print] United States |
PMID | 24672101
(Publication Type: Journal Article)
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