Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women.

Abstract

Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was carried out 7 days later. Six men and six women were included. A favorable reduction in AIx was found after vitamin D3 supplementation (P=0.042) in both genders. After vitamin D3, exclusively in women a reduction in the area under the postprandial curve for monocytes CD11b and CD35 by 10.5% (P=0.016) and 12.5% (P=0.04) and neutrophil CD11b by 17.0% (P=0.014) was observed. In conclusion, vitamin D3 probably increased postprandial arterial elasticity in men and women, but reduced postprandial leukocyte activation exclusively in women.

• Authors: B Klop, G-J M van de Geijn, E Birnie, T L Njo, H W Janssen, H G Jansen, J W Jukema, J W F Elte, M Castro Cabezas
• Journal: European journal of clinical nutrition (Eur J Clin Nutr) Vol. 68 Issue 5 Pg. 635-7 (May 2014) ISSN: 1476-5640 [Electronic] England
• PMID: 24619107 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• CD11b Antigen
• CD36 Antigens
• CR1 protein, human
• ITGAM protein, human
• Receptors, Complement 3b
• Cholecalciferol

Topics

• Adolescent
• Adult
• Area Under Curve
• Biomarkers (blood)
• CD11b Antigen (genetics, metabolism)
• CD36 Antigens (genetics, metabolism)
• Cholecalciferol (administration & dosage)
• Cross-Over Studies
• Dietary Supplements
• Dose-Response Relationship, Drug
• Female
• Humans
• Inflammation (drug therapy)
• Leukocytes (drug effects, metabolism)
• Male
• Middle Aged
• Postprandial Period (drug effects)
• Receptors, Complement 3b (genetics, metabolism)
• Vascular Stiffness (drug effects)
• Young Adult