Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment.

Abstract

Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals. Together, we demonstrate that dopamine has beneficial effects on poststroke immunodepression.

• Authors: Enida Kuric, Karsten Ruscher
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 269 Issue 1-2 Pg. 94-7 (Apr 15 2014) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 24613254 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Drug Combinations
• benserazide, levodopa drug combination
• Levodopa
• Benserazide

Topics

• Animals
• Benserazide (administration & dosage)
• Drug Combinations
• Levodopa (administration & dosage)
• Lymphopenia (drug therapy, pathology)
• Male
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Remission Induction (methods)
• Single-Blind Method
• Stroke (drug therapy, pathology)
• Treatment Outcome