Abstract | BACKGROUND: MATERIALS AND METHODS: In this multicenter, randomized, double blind, placebo-controlled study, 71 patients were randomized to 10 mg of rosuvastatin or matching placebo. Physical examination, blood sampling, echocardiography and cardiac magnetic resonance imaging were performed at baseline and at six months' follow-up. The pre-specified primary end point was the change in left ventricular ejection fraction from baseline to six months. RESULTS: Over all, left ventricular ejection fraction improved 5 percentage points over the duration of the study, but there was no difference in the change in left ventricular ejection fraction between patients allocated to rosuvastatin and those allocated to placebo. Whereas serum low density lipoprotein cholesterol concentration fell significantly in the treatment arm, rosuvastatin did not affect plasma or serum levels of a wide range of inflammatory variables, including C-reactive protein. The effect on markers of extracellular matrix remodeling was modest. CONCLUSION: TRIAL REGISTRATION: ClinicalTrials.gov NCT00505154.
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Authors | Kaspar Broch, Erik T Askevold, Erik Gjertsen, Thor Ueland, Arne Yndestad, Kristin Godang, Wenche Stueflotten, Johanna Andreassen, Rolf Svendsmark, Hans-Jørgen Smith, Svend Aakhus, Pål Aukrust, Lars Gullestad |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 2
Pg. e89732
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24586994
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, LDL
- Fluorobenzenes
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyrimidines
- Sulfonamides
- Rosuvastatin Calcium
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Topics |
- Adult
- Aged
- Cardiomyopathy, Dilated
(drug therapy, physiopathology)
- Cholesterol, LDL
(blood)
- Extracellular Matrix
(drug effects, metabolism)
- Female
- Fluorobenzenes
(therapeutic use)
- Heart Failure
(drug therapy, etiology)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Inflammation
(drug therapy)
- Male
- Middle Aged
- Pyrimidines
(therapeutic use)
- Rosuvastatin Calcium
- Sulfonamides
(therapeutic use)
- Ventricular Function, Left
(drug effects)
- Ventricular Remodeling
(drug effects)
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