Fetuin-A-containing calciprotein particle levels can be reduced by dialysis, sodium thiosulphate and plasma exchange. Potential therapeutic implications for calciphylaxis?

Abstract

Calciprotein particles (CPP) are a novel marker of mineral stress. High levels of CPP are found in patients with calciphylaxis, a condition associated with marked vascular calcification and a poor prognosis. We report substantial reductions in CPP levels in a dialysis patient having combined haemodialysis (HD) and plasma exchange (PEx) prior to an ABO-incompatible kidney transplant. We also report the effects of the same treatments combined with sodium thiosulphate (STS) in a patient newly diagnosed with calciphylaxis. Combining HD with intra-dialytic STS and PEx we achieved a significant reduction in CCP with the least rebound between treatment sessions. After 6 weeks of treatment, the CPP reduction was paralleled by clinical improvement. Measurement of CPP may be an attractive marker for monitoring the effectiveness of calciphylaxis therapy.

• Authors: Michael M X Cai, Edward R Smith, Catherine Brumby, Lawrence P McMahon, Stephen G Holt
• Journal: Nephrology (Carlton, Vic.) (Nephrology (Carlton)) Vol. 18 Issue 11 Pg. 724-7 (Nov 2013) ISSN: 1440-1797 [Electronic] Australia
• PMID: 24571743 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Asian Pacific Society of Nephrology.

Chemical References

• Thiosulfates
• alpha-2-HS-Glycoprotein
• sodium thiosulfate

Topics

• Adult
• Calciphylaxis (therapy)
• Female
• Humans
• Middle Aged
• Plasma Exchange
• Renal Dialysis
• Thiosulfates (chemistry)
• alpha-2-HS-Glycoprotein (chemistry)