Elevated troponin in septic patients in the emergency department: frequency, causes, and prognostic implications.

Abstract

BACKGROUND:

According to the "Third Universal Definition of Myocardial Infarction", cardiac troponin (cTn) is defined to be elevated, if the value is above the 99th percentile of a normal reference population. Especially in emergency medicine, this leads to pathological values more often than before this definition has been founded. Severe sepsis and septic shock frequently cause a rise of cTn, but there is only limited data about its role in septic patients in the emergency department (ED). Therefore, we investigated the frequency, main causes, and prognostic relevance of elevated high-sensitive troponin T (hsTnT) in septic patients in the ED.

METHODS:

Adults presenting at the ED with sepsis were included in the study. HsTnT was measured soon after admission. Main influencing factors were investigated, and the prognostic value was evaluated.

RESULTS:

197 of the 313 analysed patients (62.9 %) showed an elevated hsTnT, with significantly higher rates in patients with severe sepsis and septic shock than in uncomplicated sepsis. APACHE II score, creatinine, and coronary heart disease were found to influence hsTnT independently. Nevertheless, patients with uncomplicated sepsis and without relevant renal insufficiency also showed notable rates of elevated hsTnT: 51.6 % (uncomplicated sepsis) and 34.5 % (no relevant renal failure), respectively. HsTnT showed a prognostic value with higher levels in non-survivors and an AUC of 0.72, p < 0.001.

CONCLUSIONS:

In the ED, sepsis is a relevant cause of elevated cTn, which underlines the role of sepsis as a differential diagnosis in non-ACS patients with positive cTn. A rise of cTn may be an indicator of poor outcome.

• Authors: Joachim Wilhelm, Stefan Hettwer, Markus Schuermann, Silke Bagger, Franziska Gerhardt, Sandra Mundt, Susanne Muschik, Julia Zimmermann, Mroawan Amoury, Henning Ebelt, Karl Werdan
• Journal: Clinical research in cardiology : official journal of the German Cardiac Society (Clin Res Cardiol) Vol. 103 Issue 7 Pg. 561-7 (Jul 2014) ISSN: 1861-0692 [Electronic] Germany
• PMID: 24535379 (Publication Type: Journal Article, Observational Study)

Chemical References

• Troponin T
• Creatinine

Topics

• APACHE
• Aged
• Creatinine (metabolism)
• Diagnosis, Differential
• Emergency Service, Hospital
• Female
• Humans
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• Sepsis (diagnosis, physiopathology)
• Severity of Illness Index
• Shock, Septic (diagnosis, physiopathology)
• Troponin T (analysis)