Abstract | OBJECTIVES:
Statins are lipid-lowering drugs that exhibit anti-Inflammatory and immune-modulatory properties, leading to a reduction of serum levels of C-reactive protein (CRP) in the general population. DESIGN: To assess the anti-inflammatory effects of statins in HIV-infected patients, because very limited data are available today. METHODS: RESULTS: Eighty-six patients were enrolled into the study: 46 in group A and 40 in group B. After 48 weeks, patients treated with antiretroviral therapy plus rosuvastatin had significantly greater decreases in serum concentrations of all Inflammatory markers than those taking antiretroviral therapy only. Changes in mean levels of hsCRP and TNF-α were -35.1% and -22.4% in group B and -8.2% and 5.4% in group A, respectively (P < .001, for both parameters). No significant differences in immunovirological parameters and safety profile were reported across the compared groups. CONCLUSIONS:
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Authors | Leonardo Calza, Elisa Vanino, Caterina Salvadori, Roberto Manfredi, Vincenzo Colangeli, Alessandra Cascavilla, Maria Assunta Di Bari, Roberto Motta, Pierluigi Viale |
Journal | HIV clinical trials
(HIV Clin Trials)
2014 Jan-Feb
Vol. 15
Issue 1
Pg. 1-13
ISSN: 1528-4336 [Print] England |
PMID | 24518210
(Publication Type: Journal Article)
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Chemical References |
- Anti-Retroviral Agents
- Biomarkers
- Drug Combinations
- Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
- Fluorobenzenes
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Interleukin-6
- Organophosphonates
- Oxazines
- Pyrimidines
- Sulfonamides
- Tumor Necrosis Factor-alpha
- Deoxycytidine
- Rosuvastatin Calcium
- C-Reactive Protein
- Cholesterol
- Adenine
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Topics |
- Adenine
(administration & dosage, analogs & derivatives)
- Adult
- Anti-Retroviral Agents
(therapeutic use)
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Cholesterol
(blood)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Drug Combinations
- Drug Therapy, Combination
- Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
- Female
- Fluorobenzenes
(administration & dosage)
- HIV Infections
(blood, drug therapy)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(administration & dosage)
- Inflammation
(blood, drug therapy)
- Interleukin-6
(blood)
- Longitudinal Studies
- Male
- Middle Aged
- Organophosphonates
(administration & dosage)
- Oxazines
(administration & dosage)
- Pyrimidines
(administration & dosage)
- Rosuvastatin Calcium
- Sulfonamides
(administration & dosage)
- Tumor Necrosis Factor-alpha
(blood)
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