[Triage DOA screening in a case of methamphetamine and its analogue poisoning].

Abstract

CASE REPORT:

A 20-year-old woman presented with the chest pain, nausea, respiratory strange feeling, and a large quantity of sweating. On the stimulant zone of 8 groups of drugs of Triage DOA screening it showed an equivocal positivity while all of the other zones gave negative results. She denied taking drugs. No injection scar was found. And she was then hospitalized because little was known about her symptoms. When the unconscious patient was discovered at rest room inside hospital the next day, she was transferred to emergency and critical care center. In the same screening test positivity on the stimulant zone was observed, and furthermore both amphetamine and methamphetamine were detected by GCMS analysis. For 4 days positivity on the stimulant zone lasted. From the fact of disturbance of consciousness, restlessness, excitation and tachycardia, respiration disorder, and the pupil dilatation drug poisoning was deeply suspected.

DISCUSSION:

While the stimulant zone of Triage DOA showed the equivocal positivity when 7 hours has elapsed until she became aware of abnormality and hospitalized, in the same screening of 30 hours later positivity was verified clearly. Several problems derived from the detection method, pharmacokinetic factors and pharmacodynamic aspect were discussed as for the difference of the results detected.

• Authors: Shigeru Adachi, Akira Takamura, Takashi Ebihara, Yoshihiko Suzuki, Takuo Yoshida, Ryo Suzuki, Takaaki Kikuno
• Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology (Chudoku Kenkyu) Vol. 26 Issue 4 Pg. 300-4 (Dec 2013) ISSN: 0914-3777 [Print] Japan
• PMID: 24483009 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Central Nervous System Stimulants
• Methamphetamine
• Amphetamine

Topics

• Adult
• Amphetamine (blood, pharmacokinetics, poisoning)
• Central Nervous System Stimulants (blood, pharmacokinetics, poisoning)
• Female
• Gas Chromatography-Mass Spectrometry
• Humans
• Methamphetamine (blood, pharmacokinetics, poisoning)
• Substance Abuse Detection (instrumentation, methods)
• Substance-Related Disorders (diagnosis)
• Time Factors
• Triage (methods)
• Unconsciousness (chemically induced)
• Young Adult