Sensitive and selective plasmonic assay for spermine as biomarker in human urine.

Abstract

A simple, fast, and highly selective and sensitive colorimetric assay to detect nanomolar levels of spermine in human urine (healthy donors, cancer patients) is reported. This assay is based on the absence of a competitive organic capping on the gold nanoparticles together with the high affinity of the amine groups of the analyte for the nanoparticle surface.

• Authors: N Jornet-Martínez, María González-Béjar, Y Moliner-Martínez, P Campíns-Falcó, Julia Pérez-Prieto
• Journal: Analytical chemistry (Anal Chem) Vol. 86 Issue 3 Pg. 1347-51 (Feb 04 2014) ISSN: 1520-6882 [Electronic] United States
• PMID: 24428122 (Publication Type: Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Spermine
• Gold

Topics

• Biomarkers (urine)
• Colorimetry (methods)
• Gold (chemistry)
• Humans
• Limit of Detection
• Metal Nanoparticles (chemistry)
• Spermine (urine)
• Urinalysis (methods)