Abstract |
Traumatic brain injury (TBI) occurs in response to an acute insult to the head and is recognized as a major risk factor for Alzheimer's disease (AD). Indeed, recent studies have suggested a pathological overlap between TBI and AD, with both conditions exhibiting amyloid-beta (Aβ) deposits, tauopathy, and neuroinflammation. Additional studies involving animal models of AD indicate that some AD-related genotypic determinants may be critical factors enhancing temporal and phenotypic symptoms of TBI. Thus in the present study, we examined sub-acute effects of moderate TBI delivered by a gas-driven shock tube device in Aβ depositing Tg2576 mice. Three days later, significant increases in b- amyloid deposition, glycogen synthase-3 (GSK-3) activation, phospho-tau, and pro-inflammatory cytokines were observed. Importantly, peripheral treatment with the naturally occurring flavonoid, luteolin, significantly abolished these accelerated pathologies. This study lays the groundwork for a safe and natural compound that could prevent or treat TBI with minimal or no deleterious side effects in combat personnel and others at risk or who have experienced TBI.
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Authors | Darrell Sawmiller, Song Li, Md Shahaduzzaman, Adam J Smith, Demian Obregon, Brian Giunta, Cesar V Borlongan, Paul R Sanberg, Jun Tan |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 15
Issue 1
Pg. 895-904
(Jan 09 2014)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 24413756
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Amyloid beta-Peptides
- Cytokines
- tau Proteins
- Glycogen Synthase Kinase 3
- Luteolin
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Topics |
- Alzheimer Disease
(drug therapy, etiology)
- Amyloid beta-Peptides
(metabolism)
- Animals
- Brain
(drug effects, metabolism)
- Brain Injuries
(complications, drug therapy)
- Cytokines
(genetics, metabolism)
- Glycogen Synthase Kinase 3
(metabolism)
- Luteolin
(pharmacokinetics, pharmacology, therapeutic use)
- Mice
- Tissue Distribution
- tau Proteins
(metabolism)
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