Corin in natriuretic peptide processing and hypertension.

Abstract

Corin is a serine protease originally isolated from the heart. Functional studies show that corin is the long-sought enzyme responsible for activating cardiac natriuretic peptides. In mice, lack of corin prevents natriuretic peptide processing, causing salt-sensitive hypertension. In humans, corin variants and mutations that reduce corin activity have been identified in patients with hypertension and heart failure. Decreased plasma levels of corin antigen and activity have been reported in patients with heart failure and coronary artery disease. Low levels of urinary corin also have been found in patients with chronic kidney disease. Most recent studies show that corin also acts in the uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Here, we review the role of corin in natriuretic peptide processing and cardiovascular diseases such as hypertension, heart disease, pre-eclampsia, and chronic kidney disease.

• Authors: Yiqing Zhou, Qingyu Wu
• Journal: Current hypertension reports (Curr Hypertens Rep) Vol. 16 Issue 2 Pg. 415 (Feb 2014) ISSN: 1534-3111 [Electronic] United States
• PMID: 24407448 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Natriuretic Peptides
• CORIN protein, human
• Serine Endopeptidases

Topics

• Animals
• Blood Pressure (genetics)
• Heart Failure (complications)
• Humans
• Hypertension (metabolism)
• Natriuretic Peptides (genetics, metabolism)
• Serine Endopeptidases (genetics, metabolism)