Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma.

Abstract

Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. The patient was admitted to the intensive care unit with severe diabetic ketoacidosis which needed aggressive fluid resuscitation and insulin therapy. We believe it is critical to be aware of the symptoms of diabetic ketoacidosis and monitor glucose levels during streptozotocin treatment.

• Authors: M Berends, W J Lesterhuis, H W M van Laarhoven
• Journal: The Netherlands journal of medicine (Neth J Med) Vol. 71 Issue 10 Pg. 541-2 (Dec 2013) ISSN: 1872-9061 [Electronic] Netherlands
• PMID: 24394744 (Publication Type: Case Reports, Letter)

Chemical References

• Antibiotics, Antineoplastic
• Streptozocin

Topics

• Antibiotics, Antineoplastic (adverse effects, therapeutic use)
• Carcinoma, Islet Cell (drug therapy)
• Diabetic Ketoacidosis (chemically induced, diagnosis)
• Diagnosis, Differential
• Female
• Humans
• Middle Aged
• Muscle Weakness (etiology)
• Pancreatic Neoplasms (drug therapy)
• Streptozocin (adverse effects, therapeutic use)