The role of LAIR-1 (CD305) in T cells and monocytes/macrophages in patients with rheumatoid arthritis.

Abstract

The LAIR-1 receptor is expressed on a majority of mononuclear leukocytes. It is used as a biomarker when testing synovial fluid for evidence of rheumatoid arthritis (RA). The primary objective of this study was to measure T cell- and monocyte/macrophage-specific LAIR-1 expression in RA patients and compare this to LAIR-1 expression in osteoarthritis (OA) patients and healthy individuals. LAIR-1 expression was significantly decreased in circulating CD4(+) T cells in RA patients compared to both OA patients and healthy individuals. In contrast, LAIR-1 is high in CD14(+) monocytes and local CD68(+) macrophages in synovial tissues from RA patients. Upon stimulation with TNF-α, LAIR-1 expression decreased in T-helper (Th)1 and Th2 CD4(+) T cells from healthy donors. These results indicate that LAIR-1 may exert different functions on T cells and monocytes/macrophages and suggest that LAIR-1 may be a novel therapeutic target for the treatment of RA.

• Authors: Y Zhang, K Lv, C M Zhang, B Q Jin, R Zhuang, Y Ding
• Journal: Cellular immunology (Cell Immunol) Vol. 287 Issue 1 Pg. 46-52 (Jan 2014) ISSN: 1090-2163 [Electronic] Netherlands
• PMID: 24380839 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Receptors, Immunologic
• leukocyte-associated immunoglobulin-like receptor 1

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (immunology)
• Biomarkers (metabolism)
• CD4-Positive T-Lymphocytes (immunology)
• Cells, Cultured
• Female
• Gene Expression Regulation
• Humans
• Macrophages (immunology)
• Male
• Middle Aged
• Organ Specificity
• Osteoarthritis (immunology)
• Receptors, Immunologic (immunology, metabolism)
• Synovial Membrane (immunology)
• Th1-Th2 Balance