Abstract | OBJECT: METHODS:
Minocycline was incorporated into the biodegradable polymer polyanhydride poly(1,3-bis-[p-carboxyphenoxy propane]-co-[sebacic anhydride]) ( CPP:SA) at a ratio of 50:50 by weight. Female Fischer 344 rats were implanted with 9L glioma on Day 0. The minocycline polymer was then implanted on either Day 3 or Day 5 posttumor implantation. Cohorts of rats were exposed to 20 Gy focal radiation on Day 5 or were administered oral temozolomide (50 mg/kg daily) on Days 5-9. RESULTS: CONCLUSIONS:
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Authors | Hansen Bow, Lee S Hwang, Noam Schildhaus, Joanna Xing, Luke Murray, Quinn Salditch, Xiaobu Ye, Yonggang Zhang, Jon Weingart, Henry Brem, Betty Tyler |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 120
Issue 3
Pg. 662-9
(Mar 2014)
ISSN: 1933-0693 [Electronic] United States |
PMID | 24359008
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Antineoplastic Agents, Alkylating
- Polymers
- Dacarbazine
- Minocycline
- Temozolomide
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Topics |
- Administration, Oral
- Angiogenesis Inhibitors
(pharmacology, therapeutic use)
- Animals
- Antineoplastic Agents, Alkylating
(pharmacology, therapeutic use)
- Brain Neoplasms
(therapy)
- Chemoradiotherapy
(methods)
- Combined Modality Therapy
- Dacarbazine
(analogs & derivatives, pharmacology, therapeutic use)
- Disease Models, Animal
- Drug Delivery Systems
(methods)
- Female
- Gliosarcoma
(therapy)
- Minocycline
(pharmacology, therapeutic use)
- Neoplasm Transplantation
- Polymers
(pharmacology)
- Rats
- Rats, Inbred F344
- Temozolomide
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