(31) P MR spectroscopic imaging combined with (1) H MR spectroscopic imaging in the human prostate using a double tuned endorectal coil at 7T.

Abstract

PURPOSE:

Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both (1) H and (31) P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer.

METHODS:

A two-element (1) H/(31) P endorectal coil was designed by adjusting a commercially available 3T endorectal coil. The two-element coil setup was interfaced as a transceiver to a whole body 7T MR scanner. Simulations and phantom measurements were performed to compare the efficiency of the coil. (1) H MRSI and (31) P MRSI were acquired in vivo in prostate cancer patients.

RESULTS:

The efficiency of the (1) H/(31) P coil is comparable to the dual channel (1) H coil previously published. Individually distinguishable phospholipid metabolites in the in vivo (31) P spectra were: phosphoethanolamine, phosphocholine, phosphate, glycerophosphoethanolamine, glycerophosphocholine, phosphocreatine, and adenosine triposphate. (1) H MRSI was performed within the same scan session, visualizing choline, polyamines, creatine, and citrate.

CONCLUSION:

(1) H MRSI and (31) P MRSI can be acquired in the human prostate at 7T within the same scan session using an endorectal coil matched and tuned for (1) H (quadrature) and (31) P (linear) without the need of cable traps and with negligible efficiency losses in the (1) H and (31) P channel.

• Authors: Mariska P Luttje, Michel G M Italiaander, Catalina S Arteaga de Castro, Wybe J M van der Kemp, Peter R Luijten, Marco van Vulpen, Uulke A van der Heide, Dennis W J Klomp
• Journal: Magnetic resonance in medicine (Magn Reson Med) Vol. 72 Issue 6 Pg. 1516-21 (Dec 2014) ISSN: 1522-2594 [Electronic] United States
• PMID: 24357271 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Biomarkers, Tumor
• Phosphorus Radioisotopes
• Radiopharmaceuticals

Topics

• Aged
• Biomarkers, Tumor (metabolism)
• Equipment Design
• Equipment Failure Analysis
• Female
• Humans
• Magnetic Resonance Imaging (instrumentation)
• Magnetics (instrumentation)
• Male
• Middle Aged
• Phosphorus Radioisotopes (pharmacokinetics)
• Prostatic Neoplasms (metabolism, pathology)
• Proton Magnetic Resonance Spectroscopy (methods)
• Radiopharmaceuticals
• Rectum
• Reproducibility of Results
• Sensitivity and Specificity
• Transducers