Abstract |
Neonatal sepsis due to carbapenem-resistant bacteria is difficult to treat due to limited therapeutic options. The detection of the new carbapenemase New Delhi metallo-β-lactamase-1 (NDM-1) from neonates has further complicated the situation (Roy et al., 2011a). The potent metallo-β-lactamase NDM-1 efficiently hydrolyses all classes of β- lactam antibiotics ( penicillins, cephalosporins and carbapenems) and is also associated with multiple determinants that enable the bacteria to become resistant to other antibiotic classes (Nordmann et al., 2011). In the presence of NDM-1 other β-lactamases may go unobserved because of the spectrum of activity of NDM-1 against all β- lactam antibiotics. Thus, under the canopy of the NDM-1 these β-lactamases also get the opportunity to spread. This communication reports association of two novel β-lactamases, SHV-type β-lactamase (SHV-167) and AmpC-type β-lactamase (ACT-16), in two NDM-1-carrying Enterobacteriaceae isolated from the blood of two septicaemic neonates admitted to a neonatal intensive care unit.
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Authors | Saswati Datta, Shravani Mitra, Rajlakshmi Viswanathan, Anindya Saha, Sulagna Basu |
Journal | Journal of medical microbiology
(J Med Microbiol)
Vol. 63
Issue Pt 3
Pg. 480-482
(Mar 2014)
ISSN: 1473-5644 [Electronic] England |
PMID | 24336426
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Bacterial Proteins
- Carbapenems
- AmpC beta-lactamases
- beta-Lactamases
- beta-lactamase NDM-1
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Topics |
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Bacterial Proteins
(genetics)
- Base Sequence
- Carbapenems
(pharmacology)
- Disk Diffusion Antimicrobial Tests
- Drug Resistance, Bacterial
- Enterobacter cloacae
(drug effects, enzymology, genetics, isolation & purification)
- Enterobacteriaceae Infections
(microbiology)
- Humans
- India
- Infant, Newborn
- Klebsiella Infections
(microbiology)
- Klebsiella pneumoniae
(drug effects, enzymology, genetics, isolation & purification)
- Molecular Sequence Data
- Plasmids
(genetics)
- Sepsis
- Sequence Analysis, DNA
- beta-Lactamases
(genetics)
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