Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: MATERIALS AND METHODS: Electroencephalography (EEG) and electromyography (EMG) were recorded in freely moving rats and the sleep parameters were analyzed with SleepSign software. The levels of serotonin (5-HT), norepinephrine (NE), dopamine (DA) and their metabolites were examined to investigate the underlying mechanisms by using HPLC-ECD. Blood pressure was measured by noninvasive blood pressure tail cuff test. RESULTS:
Tetrandrine (100mg/kg, i.g.) significantly suppressed blood pressure of SHR rats day by day during three days treatment. Meanwhile, tetrandrine remarkably improved the sleep efficiency by increasing total sleep time, rapid eye movement (REM) sleep and non-REM (NREM) sleep (including deep sleep and light sleep) time from the first day. Three days treatment of tetrandrine induced 5-HT concentration decrease in DRN, 5-HIAA concentration increase in LC and 5-HIAA/5-HT ratio increase in VTA and LC. In contrast, no changes in NE and DA concentrations in the DRN, VTA and LC occurred in SHR after tetrandrine treatment. These results indicate that modulation of 5-HT, its metabolite 5-HIAA and the 5-HIAA/5-HT ratio in DRN, VTA and LC are likely the mechanism of antihypertensive and hypnotic effects of tetrandrine at least in part. CONCLUSION:
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Authors | Juan Zhang, Bin Yu, Xue-Qiong Zhang, Zhao-Fu Sheng, Sheng-Jie Li, Zi-Jun Wang, Xiang-Yu Cui, Su-Ying Cui, Yong-He Zhang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 151
Issue 1
Pg. 729-32
( 2014)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 24269338
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antihypertensive Agents
- Benzylisoquinolines
- tetrandrine
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Topics |
- Animals
- Antihypertensive Agents
(chemistry, pharmacology)
- Benzylisoquinolines
(chemistry, pharmacology)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Sleep
(drug effects)
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