Relation between serum osteocalcin levels and body composition in obese children.

Abstract

Overweight and obesity may contribute to bone fractures in children; however, the mechanism involved is not clear. In this study, we assessed the relation between serum osteocalcin levels and body composition in obese children. A total of 79 children (ages 7-12 years) were recruited. Serum osteocalcin levels were negatively correlated with fat percentage and visceral fat area (r = -0.24 and r = -0.46, respectively, P < 0.05); however, no statistically significant association was found between obesity degree and serum osteocalcin levels (r = -0.29, P = 0.052). Serum osteocalcin levels were positively correlated with lean body mass, fat-free mass, and fat-free mass index (r = 0.24, 0.23, and 0.31, respectively; P < 0.05). In addition, serum osteocalcin levels were significantly lower in severely obese (44.46 ± 9.73 μg/mL) and moderately obese (48.72 ± 10.82 μg/mL) children than in mildly obese (55.43 ± 12.4 μg/mL) and overweight (54.36 ± 11.96 μg/mL) children (P = 0.02). These findings indicate that body composition is related to serum osteocalcin levels in overweight and obese children.

• Authors: Jing-Wen Wang, Qing-Ya Tang, Hui-Juan Ruan, Wei Cai
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 58 Issue 6 Pg. 729-32 (Jun 2014) ISSN: 1536-4801 [Electronic] United States
• PMID: 24253362 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Osteocalcin

Topics

• Biomarkers (blood)
• Body Composition
• Body Fat Distribution
• Body Fluid Compartments (metabolism)
• Body Mass Index
• Bone and Bones (metabolism)
• Child
• Female
• Fractures, Bone (blood, etiology)
• Humans
• Intra-Abdominal Fat (metabolism)
• Male
• Obesity, Morbid (blood)
• Osteocalcin (blood)
• Overweight
• Pediatric Obesity (blood, complications)