Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors.

Abstract

BACKGROUND/AIM:

Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor.

MATERIALS AND METHODS:

A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.

RESULTS:

The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed.

CONCLUSION:

The chemoprevention diet had a protective effect against tumor development in the mouse lungs.

• Authors: Hans-Christian Pommergaard, Jakob Burcharth, J Rosenberg, Hans Raskov
• Journal: Anticancer research (Anticancer Res) Vol. 33 Issue 11 Pg. 4767-70 (Nov 2013) ISSN: 1791-7530 [Electronic] Greece
• PMID: 24222111 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Bone Density Conservation Agents
• Calcium, Dietary
• Carcinogens
• Vitamin D
• Aspirin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Aspirin (administration & dosage)
• Bone Density Conservation Agents (administration & dosage)
• Calcium, Dietary (administration & dosage)
• Carcinogens (toxicity)
• Diet
• Disease Models, Animal
• Lung Neoplasms (chemically induced, pathology, prevention & control)
• Mice
• Mice, Inbred A
• Tobacco (toxicity)
• Vitamin D (administration & dosage)