Gastrointestinal sensitivity and gastroesophageal reflux disease.

Abstract

This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.

• Authors: Annamaria Altomare, Michele Pier Luca Guarino Sara Emerenziani, Michele Cicala, Asbjørn Mohr Drewes, Anne Lund Krarup, Christina Brock, Christian Lottrup, Jens Brøndum Frøkjaer, Rhonda F Souza, Gerardo Nardone, Debora Compare
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1300 Pg. 80-95 (Oct 2013) ISSN: 1749-6632 [Electronic] United States
• PMID: 24117636 (Publication Type: Journal Article, Review)
• Copyright: © 2013 New York Academy of Sciences.

Chemical References

• Receptors, Purinergic
• TRPV Cation Channels
• TRPV1 protein, human

Topics

• Gastroesophageal Reflux (metabolism, physiopathology)
• Gastrointestinal Tract (metabolism, physiopathology)
• Humans
• Pain (metabolism, physiopathology)
• Receptors, Purinergic (metabolism)
• TRPV Cation Channels (metabolism)