Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins.

Abstract

Antigenic relatedness between the virion-associated proteins of caprine arthritis-encephalitis, visna and progressive pneumonia viruses was examined. Antigenic cross-reactivity was assessed by immunoprecipitation of disrupted, radiolabelled virus with goat, sheep and rabbit antisera, followed by resolution of the immunoprecipitation products by SDS-polyacrylamide gel electrophoresis. The results indicate that antigenic cross-reactivity between the caprine and ovine virus isolates involves all of the major virion-associated proteins and glycoproteins. The common antigenic determinants exhibited by virion structural proteins are immunogenic in goats, sheep and rabbits.

• Authors: R P Gogolewski, D S Adams, T C McGuire, K L Banks, W P Cheevers
• Journal: The Journal of general virology (J Gen Virol) Vol. 66 ( Pt 6) Pg. 1233-40 (Jun 1985) ISSN: 0022-1317 [Print] England
• PMID: 2409223 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Viral
• Epitopes
• Glycoproteins
• Viral Core Proteins
• Viral Envelope Proteins
• Viral Proteins

Topics

• Animals
• Antigens, Viral (immunology)
• Arthritis, Infectious (microbiology, veterinary)
• Chemical Precipitation
• Cross Reactions
• Electrophoresis, Polyacrylamide Gel
• Encephalitis (microbiology, veterinary)
• Epitopes (immunology)
• Female
• Glycoproteins (immunology)
• Goats (immunology, microbiology)
• Immunochemistry
• Rabbits (immunology)
• Sheep (immunology)
• Viral Core Proteins
• Viral Envelope Proteins (immunology)
• Viral Proteins (immunology)
• Virion (immunology)
• Visna-maedi virus (immunology)