Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes.

Abstract

BACKGROUND:

Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. T-helper (Th)2 cytokines seems to have major roles behind the scene of unpleasant symptoms resulted from AR. Expression of interleukin (IL)-4 and its receptor could be affected by single nucleotide polymorphisms (SNPs). This study assessed the effect of 4 genetic variants within genes of IL-4 and IL-4R in AR.

METHODS:

Allele frequencies of one IL-4R variant (rs1801275) and three SNPs of IL-4 (rs2243248, rs2243250, and rs2070874) were investigated in 98 patients with AR, compared to a group of controls, using PCR sequence-specific-primers (PCR-SSP) method.

RESULTS:

Homozygosity for the C allele of rs2243250 in IL-4 was significantly overrepresented in the patient group. CC genotype in rs2070874 significantly was correlated with AR. GG/CC/CC and TT/TT/TT (rs2243248, rs2243250, and rs2070874) haplotypes in the IL-4 gene had a significant negative correlation with AR.

CONCLUSION:

SNPs in IL-4 are associated with AR and could change the clinical picture of the disease in patients.

• Authors: Masoud Movahedi, Ali Akbar Amirzargar, Rasoul Nasiri, Armin Hirbod-Mobarakeh, Elham Farhadi, Marzieh Tavakol, Nasrin Behniafard, Bita Ansaripour, Batoul Moradi, Ahad Zare, Nima Rezaei
• Journal: American journal of otolaryngology (Am J Otolaryngol) 2013 Nov-Dec Vol. 34 Issue 6 Pg. 676-81 ISSN: 1532-818X [Electronic] United States
• PMID: 24075353 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Receptors, Interleukin-4
• Interleukin-4

Topics

• Case-Control Studies
• Eosinophils (metabolism)
• Female
• Gene Frequency
• Genotype
• Haplotypes
• Homozygote
• Humans
• Interleukin-4 (genetics)
• Male
• Phenotype
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide
• Receptors, Interleukin-4 (genetics)
• Rhinitis, Allergic, Perennial (genetics)
• Rhinitis, Allergic, Seasonal (genetics)