[Th17 cells and IL-17 are increased in patients with brain metastases from the primary lung cancer].

Abstract

BACKGROUND AND OBJECTIVE:

Th17 cells are important T helper cells, which are characterized by their production of IL-17. Th17 cells play an important role in host defense against microbial infections, autoimmune diseases and cancer. The aim of this study is to investigate the percentage of Th17 in peripheral blood lymphocyte and the level of IL-17 in serum and cerebrospinal fluid (CSF) in patients with brain metastases from lung cancer.

METHODS:

Twenty-two patients with brain metastases from lung cancer and 20 health controls were analyzed. The percentage of Th17 cell was detected with flow cytometry using CD3+CD4+IL-23R+ marker, the level of IL-17 was measured with ELISA method.

RESULTS:

The percentage of Th17 cells in patients with brain metastases from lung cancer was 4.65%±0.72%, which was remarkably higher than that in controls (2.71%±0.54%, P=0.04). There was no significant difference between non-small cell lung cancer (NSCLC) patients and small cell lung cancer (SCLC) patients. Serum IL-17 was remarkably increased in patients with brain metastases from lung cancer (117.4±16.43 pg/mL vs 72.55±8.19 pg/mL, P=0.02). No significant difference of the serum IL-17 was observed between NSCLC and SCLC patients. The level of IL-17 in CSF from patients with brain metastases from lung cancer was significant higher than that from lung cancer patients without brain metastases (73.21±7.52 pg/mL vs 50.25±8.04 pg/mL, P=0.04).

CONCLUSIONS:

Th17 cells and IL-17 increase in patients with brain metastases from lung cancer. It may involve in the pathogenesis of brain metastases from lung cancer.

• Authors: Gaiping He, Bin Zhang, Baowen Zhang, Liangjie Qiao, Zhonglan Tian, Guoyan Zhai, Xianwei Xin, Chun Yang, Peigang Liu, Yong Zhang, Lingling Xu
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 16 Issue 9 Pg. 476-81 (Sep 2013) ISSN: 1999-6187 [Electronic] China
• PMID: 24034995 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-17

Topics

• Adult
• Aged
• Brain Neoplasms (immunology, secondary)
• CD4 Lymphocyte Count
• Female
• Flow Cytometry
• Humans
• Interleukin-17 (blood, cerebrospinal fluid, immunology)
• Lung Neoplasms (immunology, pathology)
• Male
• Middle Aged
• Neoplasm Metastasis
• Th17 Cells (immunology)