Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway.

Abstract

Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties. We report here on the anticancer effect of ziyuglycoside II on human gastric carcinoma BGC-823 cells. We investigated the effects of ziyuglycoside II on cell growth, cell cycle, and cell apoptosis of this cell line. Our results revealed that ziyuglycoside II could inhibit the proliferation of BGC-823 cells by inducing apoptosis but not cell cycle arrest, which was associated with regulation of Bax/Bcl-2 expression, and activation of the caspase-3 pathway. Our study is the first to report the antitumor potential of ziyuglycoside II in BGC-823 gastric cancer cells. Ziyuglycoside II may become a potential therapeutic agent against gastric cancer in the future.

• Authors: A K Zhu, H Zhou, J Z Xia, H C Jin, K Wang, J Yan, J B Zuo, X Zhu, T Shan
• Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 46 Issue 8 Pg. 670-5 (Aug 2013) ISSN: 1414-431X [Electronic] Brazil
• PMID: 23969976 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Caspase Inhibitors
• Proto-Oncogene Proteins c-bcl-2
• Saponins
• bcl-2-Associated X Protein
• ziyuglycoside II
• Caspase 3
• Fluorouracil

Topics

• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects)
• Carcinoma (drug therapy)
• Caspase 3 (drug effects, metabolism)
• Caspase Inhibitors (metabolism)
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Fluorometry
• Fluorouracil (pharmacology)
• Humans
• Proto-Oncogene Proteins c-bcl-2 (drug effects, metabolism)
• Sanguisorba (chemistry)
• Saponins (pharmacology)
• Signal Transduction (drug effects)
• Stomach Neoplasms (drug therapy)
• bcl-2-Associated X Protein (drug effects, metabolism)