Abstract | OBJECTIVES: Studies have reported the significance of circulating microRNAs ( miRNAs) as biochemical markers of cancer. Few reports demonstrate the significance of miRNAs in the serum of patients with ovarian epithelial carcinoma (EOC). The present study prospectively investigated the status of miRNA-92 (miR-92) in the serum of EOC patients and healthy controls, and examined the potential usefulness of this molecule as a biomarker for EOC diagnosis. METHODS: Levels of miR-92 in serum samples from EOC patients and controls were measured by quantitative real time reverse transcription-polymerase chain reaction (RT-PCR). Associations between serum miR-92 concentrations and clinical parameters were assessed by Fisher's exact probability test. RESULTS: The serum concentration of miR-92 in EOC patients (n = 50) was significantly higher than in controls (n = 50). There were significant correlations between miR-92 expression and regional lymph node involvement and clinical stage of the tumour. There was no significant association between expression of miR-92 and age. CONCLUSION: The detection of miR-92 levels in the serum might serve as a new tumour biomarker in the diagnosis and assessment of prognosis of EOC.
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Authors | Fengjun Guo, Jingyan Tian, Yang Lin, Yuemei Jin, Ling Wang, Manhua Cui |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 41
Issue 5
Pg. 1456-61
(Oct 2013)
ISSN: 1473-2300 [Electronic] England |
PMID | 23963852
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- MIRN92 microRNA, human
- MicroRNAs
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Topics |
- Biomarkers, Tumor
(blood, genetics)
- Carcinoma, Ovarian Epithelial
- Case-Control Studies
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Likelihood Functions
- Lymphatic Metastasis
- MicroRNAs
(blood, genetics)
- Middle Aged
- Neoplasm Staging
- Neoplasms, Glandular and Epithelial
(blood, diagnosis, genetics, pathology)
- Ovarian Neoplasms
(blood, diagnosis, genetics, pathology)
- Prognosis
- Prospective Studies
- ROC Curve
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